Antiphospholipid antibodies effect over trophoblast cell function and pharmacological modulation
نویسندگان
چکیده
منابع مشابه
Reply: In vitro culture conditions, antiphospholipid antibodies and trophoblast function.
Sir, WethankDrsClark andLaskin for their interest in our recentlypublished systematic review of the effects of antiphospholipid antibodies on cultured placental cells in vitro.We agreewithmany of the authors’ comments and their suggestions for future investigations. However, in suggesting that trophoblast plugs prevent antiphospholipid antibodies accessing the placenta in early gestation, we be...
متن کاملLETTERS TO THE EDITOR In vitro culture conditions, antiphospholipid antibodies and trophoblast function
Sir, We read with interest the review of in vitro effects of antiphospholipid antibodies (aPL) on placental cell cultures by Tong et al. (2015).We congratulate the authors on this comprehensive evaluation of the literature to date. Dr Tong and colleagues conceded the limitations on their ability to draw conclusions, notably the heterogeneity of the studies including variable placental models, s...
متن کاملNovel Mechanisms Of Trophoblast Responses To Antiphospholipid Antibodies And Therapeutics In Obstetric Antiphospholipid Syndrome
Obstetric antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by circulating antiphospholipid antibodies (aPL) and an increased risk of recurrent pregnancy loss and preeclampsia. Current treatments, such as low molecular weight heparin (LMWH) may maintain pregnancy but do not reduce the risk of these late gestational complications. aPL trigger placental inflammation ...
متن کاملAntiphospholipid antibodies in homozygous sickle cell disease.
Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. Slightly increased levels of IgG antiphospholipid antibodies were found in nine patients with sickle cell disease and in none of the control subjects. Serial control samples confirmed the increased...
متن کاملAntiphospholipid antibodies.
Antiphospholipid antibodies (APLAs) are proteins that may be present in the blood and may increase your risk for blood clots or pregnancy losses. If you have a history of blood clots or recurrent pregnancy losses, you may have been tested for the presence of APLAs in your blood. The purpose of this Cardiology Patient Page is to provide information for persons with APLAs about the disorder and a...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2015
ISSN: 1664-3224
DOI: 10.3389/conf.fimmu.2015.05.00228